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. 2017 Jul 19;7:5894. doi: 10.1038/s41598-017-05927-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Three examples of expression-age trajectories among clusters of synapse-related and up-down-enriched GO BP categories (Group 9 in Fig. 3). The y-axis shows the scaled expression level and x-axis shows the age of samples on the fourth root scale. The spline curves indicate the mean expression change with age among cluster member genes for each dataset and brain region (for all of the clusters see Figure S11). The three clusters were chosen for showing peak expression at ages earlier or later than 20 years of age.