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. 2017 Jul 5;6(2):e8. doi: 10.2196/ijmr.7612

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©Reginald Gorczynski, Geoffrey Hoffmann. Originally published in the Interactive Journal of Medical Research (http://www.i-jmr.org/), 05.07.2017.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Interactive Journal of Medical Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.i-jmr.org/, as well as this copyright and license information must be included.

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Inflammatory colitis in mice receiving C3H anti-anti-C3H antibodies plus BL/6 anti-C3H IgG antibodies. The upper left panel shows attenuation of weight loss in C57BL/6mice receiving antibody treatment. * P<.05 compared with control diet; ** P<.05 compared with high fat diet and control Ig (Mann-Whitney U test). The upper right panel shows diminished changes in colon length caused by DSS and high fat diet in mice receiving antibody treatment. * P<.05 compared with control diet; ** P<.05 compared with DSS/high fat diet and control Ig (Man Whitney U test). Finally, data in the lower panel shows attenuation of cytokine mRNA expression in DSS colitis after antibody infusion. Mice received 10µg of each of the antibodies intravenously on days -14 and -7 prior to the commencement of DSS and high fat diet on day 0. * P<.05 compared with control diet; ** P<.05 compared with high fat diet and control Ig (Mann-Whitney U test).