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. 2017 Jul 5;6(2):e8. doi: 10.2196/ijmr.7612

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©Reginald Gorczynski, Geoffrey Hoffmann. Originally published in the Interactive Journal of Medical Research (http://www.i-jmr.org/), 05.07.2017.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Interactive Journal of Medical Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.i-jmr.org/, as well as this copyright and license information must be included.

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Attenuation of immune responses in 8/group OVA-immunized mice receiving combination treatment with anti-C3H and anti-anti-C3H Ig. Mice received OVA-in alum on days 0, 10, and 42, with some groups also receiving egg white solution (EWS) in the drinking water from days 14-42. Ig was infused weekly iv from day 7-35. Mice were sacrificed at day 49. Left hand panel shows IgE serum responses, while right hand panels shows attenuation of IL-4 production (ELISA) at 72hr from OVA-stimulated splenocytes of the same mice. *indicates significantly greater than controls receiving only OVA-in alum (far left), P<.05 (MANOVA); ** indicates significantly reduced relative to all other groups receiving OVA-alum and EWS, P<.05 (MANOVA).