Table 1.
Growth inhibitory activity of Hsp90 inhibitors against Plasmodium falciparum
| 3D7 | W2 | ||||||
|---|---|---|---|---|---|---|---|
| IC50 (nM) | CI 95% | IC90 (nM) | IC50 (nM) | CI 95% | IC90 (nM) | ||
| CQ | * | 37.9 | 35.7–40.0 | 67.2 | 128.7 | 118.4–138.9 | 389.7 |
| DHA | * | 1.2 | 1.1–1.3 | 5.2 | 0.5 | 0.4–0.6 | 1.8 |
| Ansamycin | |||||||
| Geldanamycin | 214.8 | 180.1–249.5 | 1700.0 | 200.2 | 153.3–247.1 | 2625.3 | |
| 17-DMAG | * | 118.1 | 109.4–126.7 | 286.6 | 169.5 | 153.3–185.7 | 541.9 |
| 17-AAG | * | 387.5 | 277.7–497.4 | 8843.3 | 161.3 | 100.1–222.4 | 9569.7 |
| Resorcinol | |||||||
| AT13387 | 665.0 | 577.2–752.9 | 4570.9 | 530.7 | 418.2–643.3 | 5369.2 | |
| NVP-AUY922 | 75.5 | 67.2–83.7 | 646.1 | 75.4 | 64.7–86.0 | 460.2 | |
| STA-9090 | 1254 | 982.7–1525 | 4110.6 | 1294 | 488.1–2101 | >10.000 | |
| Benzamides | |||||||
| SNX-5422 | 2136 | 161.9–2661 | 4322.6 | 2008 | 1155–2860 | 6648.4 | |
| SNX-2112 | * | 665.0 | 577.2–752.9 | 4570.9 | 1702 | 697.4–2707 | >10.000 |
| Purines | |||||||
| PUH71 | 3920 | 3410–4430 | >10.000 | 4420 | 3930–4910 | >10.000 | |
| PUWS13 | * | 7000 | 6180–7820 | >10.000 | 3880 | 3400–4360 | 9060 |
IC50 and IC90 values and their confidence interval (CI) at 95% confidence level are presented
* Significant differences between strains (two-tailed, t test P < 0.05)