Fig. 4.

The contribution of IMF-associated OTUs to the function shifts of IMF-associated KEGG pathways. For each pathway, the sum of OTU contribution scores matches the observed OTU-based functional shift score. For each function term, the bar on the top-right of Y axis represents high IMF-associated OTUs driving functional shift; the bar on the top-left of Y axis indicates high IMF-associated OTUs attenuating functional shift; the bar on the bottom-right of Y axis represents low IMF-associated OTUs driving functional shift; the bar on the bottom-left of Y axis shows low IMF-associated OTUs attenuating functional shift. a Cecum lumen samples. b Fecal samples