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Structure of WW-domain binding protein 2. The N-terminal domain is PH-GRAM, which serves as the Rab-like GTPase activators. There are three PPxY motif within the proline-rich domain of the C-terminal region and they can recognize WW-domain containing proteins and perform a variety of biological functions. Tyrosine kinase activates Tyr192 and Tyr231 sites of WBP2 and activation of WBP2 enter the nucleus to function ability of transcriptional coactivator
