Figure 1.

PD attenuates podocyte apoptosis in KKAy mice. Male C57BL/6J and KKAy mice were administered PD (100/kg/day) for 8 weeks, (a) Kidney histology (×200). (b) TEM (×25,000) of renal tissue from KKAy mice. (c) The quantitative analysis of the slit width. (d) The influence of PD treatment on protein levels of nephrin and podocin. CTRL, C57BL/6J mice treated with vehicle; DIAB, KKAy mice treated with vehicle; DIAB + PD, KKAy mice treated with PD; CTRL + PD, C57BL/6J mice treated with PD. Data are presented as the mean ± SE (n = 10). *p < 0.05 versus CTRL; #p < 0.05 versus DIAB