Table 1.
Associations between CIMP and clinical‐ and molecular features stratified by MSI status.
| MSS | MSI | |||||||
|---|---|---|---|---|---|---|---|---|
|
Total n |
CIMP− n (%) |
CIMP+ n (%) |
P value |
Total n |
CIMP− n (%) |
CIMP+ n (%) |
P value | |
| No. of patients | 933 | 871 (93) | 62 (7) | 180 | 37 (21) | 143 (79) | ||
| Gender | 0.004 | 0.024 | ||||||
| Male | 474 | 454 (96) | 20 (4) | 50 | 16 (32) | 34 (68) | ||
| Female | 459 | 417 (91) | 42 (9) | 130 | 21 (16) | 109 (84) | ||
| Age | 0.597 | <0.001 | ||||||
| <60 | 170 | 159 (94) | 11 (6) | 23 | 13 (57) | 10 (43) | ||
| 60–74 | 367 | 339 (92) | 28 (8) | 63 | 11 (17) | 52 (83) | ||
| ≥75 | 396 | 373 (94) | 23 (6) | 94 | 13 (14) | 81 (86) | ||
| Stage | <0.001 | 0.475 | ||||||
| I | 166 | 165 (99) | 1 (1) | 22 | 6 (27) | 16 (73) | ||
| II | 333 | 316 (95) | 17 (5) | 105 | 20 (19) | 85 (81) | ||
| III | 258 | 236 (91) | 22 (9) | 40 | 10 (25) | 30 (75) | ||
| IV | 173 | 151 (87) | 22 (13) | 13 | 1 (8) | 12 (92) | ||
| Localization | <0.001 | <0.001 | ||||||
| Right colon | 301 | 260 (86) | 41 (14) | 151 | 22 (15) | 129 (85) | ||
| Left colon | 329 | 314 (95) | 15 (5) | 18 | 7 (39) | 11 (61) | ||
| Rectum | 289 | 284 (98) | 5 (2) | 8 | 6 (75) | 2 (25) | ||
| BRAF | <0.001 | <0.001 | ||||||
| BRAF wt | 825 | 792 (96) | 33 (4) | 53 | 30 (57) | 23 (43) | ||
| BRAF mut | 55 | 28 (51) | 27 (49) | 111 | 3 (3) | 108 (97) | ||
| MLH1methylation | 0.024 | <0.001 | ||||||
| MLH1 unmeth | 929 | 869 (94) | 60 (6) | 35 | 25 (71) | 10 (29) | ||
| MLH1meth | 4 | 2 (50) | 2 (50) | 145 | 12 (8) | 133 (92) | ||
Meth, methylated; mut, mutation; No., number; unmeth, unmethylated; wt, wild type.