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. 2017 May 11;122(6):1639–1656. doi: 10.1111/jam.13459

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© 2017 The Authors. Journal of Applied Microbiology published by John Wiley & Sons Ltd on behalf of The Society for Applied Microbiology.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Cytoscape visualization illustrates the metabolic pathways most differentially regulated between treatments. Cytoscape visualization of (a) lipid and (b) amino acid metabolic pathways that differ between LP and LP+RBE. For each metabolite, node diameter is proportional to the fold difference in LP+RBE compared to LP. Node colours indicate the direction of a metabolite's fold difference, where red indicates metabolites with a higher scaled abundance in LP+RBE (P < 0·05), blue indicates lower abundance in LP+RBE (P < 0·05), pink indicates trending higher in LP+RBE (0·05 < P < 0·10), and light blue indicates trending lower in LP+RBE (0·05 < P < 0·10). Black nodes indicate metabolites with fold differences that were not significantly altered between treatments. The pathway enrichment score is the number in the circles for each subclassification.