. Author manuscript; available in PMC: 2017 Jul 20.

Published in final edited form as: ChemMedChem. 2014 Aug 22;9(11):2463–2474. doi: 10.1002/cmdc.201402235

Table 4.

Half-lives of fluorescently labeled peptides as determined by degradation profiles in human blood plasma and porcine liver extract homogenates.

No.	Modification		Blood plasma		Liver homogenate
No.	N-terminal	Side chain	t_1/2±SEM [h]	P value^[a]	t_1/2±SEM [h]	P value^[a]
14b	TAMRA	–	84.7 ± 2.3	–	11.0 ± 0.4	–
15b	TAMRA	E-Prop	473.6 ± 17.3	≤ 0.001	46.7 ± 6.6	≤0.01
16b	TAMRA	E-Capr	281.3 ± 26.7	≤0.01	14.6 ± 2.8	ns
18b	TAMRA	E-Pam	1088.1 ± 282.4	≤ 0.001	11.8± 0.8	ns
20	–	TAMRA	136.0 ± 3.1	ns	19.7 ± 0.4	ns

^[a]

Statistical significance of t_1/2 values was determined by one-way ANOVA, followed by Dunnett's post-hoc test (GraphPad Prism 5.0) with comparison to control peptide 14b; ns: not significant.