Table 2.
Immunohistochemical and molecular profile of spindle cell/sclerosing RMS
| Immunohistochemical stains | Molecular | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case # | Myogenin | Desmin | MyoD1 | SMA | CK | CD99 | MYOD1 | PIK3CA | SRF-NCOA2 | PAX3/7-FOXO1 |
| 1a,b | +(f) | + | + | − | − | L122R (heterozygous) | E542V | − | − | |
| 2a,b,c | +(f) | + | − | − | + | L122R (homozygous) | E542K | − | − | |
| 3 | + | + | + | − | − | WT | WT | − | ||
| 4 | +(f) | + | + | − | ||||||
| 5 | + | + | +(f) | − | − | L122R (heterozygous) | WT | − | ||
| 6 | +(f) | + | + | +(f) | + | WT | WT | |||
| 7 | +(f) | +(f) | + | − | WT | WT | ||||
| 8a,c | +(f) | + | + | + | ||||||
| 9 | +(f) | + | +(f) | WT | WT | |||||
| 10 | +(f) | + | + | − | − | |||||
| 11 | +(f) | + | +(f) | − | WT | WT | ||||
| 12 | +(f) | + | + | − | − | − | ||||
| 13 | +(f) | + | − | WT | WT | − | − | |||
a,b, c
Cases included in Mosquera et al., Agaram et al. and Alaggio et al.
(+) – Positive, (−) – negative, f – focal, SMA – smooth muscle actin, CK - cytokeratin, WT – wild type