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. 2017 May 31;65(8):1350–1360. doi: 10.1002/glia.23167

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© 2017 The Authors GLIA Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The percentage of myelinated damaged axons increased during remyelination. (a) Unmyelinated and myelinated APP⁺ axons were observed in the corpus callosum of mice after demyelination and during remyelination. A representative image of the corpus callosum 3 and 4 days after withdrawal of cuprizone is shown. (b) APP⁺ axons were analyzed in 30 randomly selected areas with at least one APP⁺ axon (approx. 50 axons) in the corpus callosum of mice by confocal microscopy. After 1 week of recovery the number of myelinated APP⁺ axons increased significantly indicating remyelination of damaged axons (**p < 0.01; n = 3‐7; mean ± SEM)