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. 2017 May 31;65(8):1350–1360. doi: 10.1002/glia.23167

Figure 4.

Figure 4

Significant reduction of acute axonal damage during lesion repair in lysolecithin‐induced demyelination.

(a) Representative images of lysolecithin‐induced lesions in the rat corpus callosum on days 6 and 20 postinjection. LFB‐PAS histochemistry revealed almost complete demyelination after 6 days and almost complete remyelination after 20 days.

APP+ axons were observed in lysolecithin‐induced lesions. (b) The number of APP+ axons in the lesions increased until day 6 and showed a significant decrease on day 20 after lysolecithin injection (*p<0.05; n = 3‐5; mean ± SD)