Table 5.
Response (%) to radiation therapy (n = 94 by site)a)
| By patient (n = 44) |
By site (n = 94)a) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Univariate |
Multivariate |
Univariate |
Multivariate |
|||||||
| No. (%) | 1-yr LC (%) | p-valueb) | HR (95% CI) | p-valueb) | No. (%) | 1-yr LC (%) | p-valueb) | HR (95% CI) | p-valueb) | |
| Histologic subtype | ||||||||||
| Clear cell, mucinous, endometrioid | 7 (15.9) | - | NS | - | NS | 12 (12.8) | 41.7 | 0.009 | 3.4 (1.4–8.1) | 0.001 |
| Serous, others | 37 (84.1) | 82 (87.2) | 78.0 | |||||||
| Response to adjuvant chemotherapy | ||||||||||
| Resistant | 17 (38.6) | - | NS | - | NS | 46 (48.9) | 67.4 | 0.002 | 2.4 (1.2–5.0) | 0.019 |
| Sensitive | 27 (61.4) | 48 (51.1) | ||||||||
| BED (Gy) | ||||||||||
| ≥50 | 22 (50.0) | 77.3 | 0.042 | - | NS | 51 (54.3) | 80.4 | 0.001 | 0.4 (0.2–0.9) | 0.025 |
| <50 | 22 (50.0) | 63.6 | 43 (45.7) | 65.1 | ||||||
| Site treated | ||||||||||
| Distant | 21 (47.7) | 66.7 | 0.047 | 3.3 (1.6–9.5) | 0.026 | 45 (47.9) | 71.1 | 0.015 | - | NS |
| Regional or nodal | 23 (52.3) | 73.9 | 49 (52.1) | 75.6 | ||||||
| Number of lesions at time of RT | ||||||||||
| Multiple | 32 (72.7) | - | NS | - | NS | |||||
| Single | 12 (27.3) | |||||||||
HR, hazard ratio; CI, confidence interval; RT, radiotherapy; BED, biologically effective dose; NS, not significant.
a)
Each cumulative site counted separately for patients that received multiple courses of irradiation.
b)
Cox proportional hazard model.