Table 1.

Region of Interest Analysis of Dose Sensitivity: Linear mixed model coefficients (percent change per Gy) and p-values

Region of Interest	FA		MD(× 10−6 mm2/s)		λ‖(× 10−6 mm2/s)		λ⊥(× 10−6 mm2/s)
Dose	Coefficient	p-value	Coefficient	p-value	Coefficient	p-value	Coefficient	p-value
Anterior corona radiata
Mean	−0.03	NS	0.09	.007	0.07	.014	0.10	.121
Max	−0.03	NS	0.07	.001	0.06	.004	0.08	.030
Anterior limb of internal capsule
Mean	0.01	NS	−0.08	.002	−0.05	.117	−0.11	.005
Max	0.01	NS	−0.06	.008	−0.04	.235	−0.08	.016
Body of corpus callosum
Mean	−0.23	<.001	0.09	.016	−0.05	NS	0.27	<.001
Max	−0.16	<.001	0.07	.006	−0.03	NS	0.19	<.001
Cingulum bundle
Mean	−0.44	<.001	0.12	<.001	−0.07	.003	0.28	<.001
Max	−0.32	<.001	0.09	<.001	−0.04	.025	0.21	<.001
Cingulum (parahippocampal)
Mean	−0.16	<.001	−0.03	NS	−0.07	.008	−0.01	NS
Max	−0.12	<.001	−0.01	NS	−0.04	.106	0.01	NS
Corticospinal tract
Mean	−0.10	NS	−0.05	NS	−0.06	.472	−0.05	NS
Max	−0.07	NS	−0.03	NS	−0.03	NS	−0.03	NS
External capsule
Mean	−0.02	NS	−0.01	NS	−0.01	NS	0.00	NS
Max	−0.01	NS	0.00	NS	0.00	NS	0.01	NS
Fornix (column and body of fornix)
Mean	−0.46	<.001	0.23	<.001	0.04	NS	0.40	<.001
Max	−0.40	<.001	0.20	<.001	0.03	NS	0.35	<.001
Fornix (cres)/Stria terminalis
Mean	−0.11	.014	−0.02	NS	−0.08	<.001	0.05	NS
Max	−0.10	.005	−0.01	NS	−0.06	.001	0.05	NS
Genu of corpus callosum
Mean	−0.12	.312	0.10	.035	0.04	NS	0.16	.009
Max	−0.09	.074	0.07	.007	0.02	NS	0.13	<.001
Posterior corona radiate
Mean	0.03	NS	−0.02	NS	0.00	NS	−0.03	NS
Max	0.02	NS	0.00	NS	0.01	NS	−0.01	NS
Posterior limb of internal capsule
Mean	0.17	<.001	−0.08	.001	0.02	NS	−0.20	<.001
Max	0.13	<.001	−0.06	.010	0.02	NS	−0.14	<.001
Posterior thalamic radiation
Mean	−0.02	NS	−0.01	NS	−0.04	NS	0.03	NS
Max	−0.02	NS	0.00	NS	−0.02	NS	0.04	NS
Retrolenticular part of internal capsule
Mean	0.08	.385	−0.03	NS	0.00	NS	−0.07	NS
Max	0.06	NS	−0.02	NS	0.00	NS	−0.05	NS
Sagittal stratum
Mean	0.00	NS	−0.02	NS	−0.03	NS	−0.01	NS
Max	−0.01	NS	−0.01	NS	−0.02	NS	0.00	NS
Splenium
Mean	−0.12	.054	0.07	.270	−0.02	NS	0.17	<.001
Max	−0.10	.008	0.06	.039	−0.01	NS	0.14	<.001
Superior corona radiate
Mean	0.05	NS	−0.02	NS	0.01	NS	−0.06	NS
Max	0.04	NS	−0.01	NS	0.02	NS	−0.03	NS
Superior fronto-occipital fasciculus
Mean	0.08	NS	0.10	.001	0.10	<.001	0.10	.075
Max	0.06	NS	0.09	<.001	0.09	<.001	0.09	.025
Superior longitudinal fasciculus
Mean	−0.02	NS	−0.03	NS	−0.03	NS	−0.03	NS
Max	−0.02	NS	−0.02	NS	−0.02	NS	−0.01	NS
Tapetum
Mean	−0.09	.384	0.16	<.001	0.10	<.001	0.22	<.001
Max	−0.09	.076	0.15	<.001	0.09	<.001	0.20	<.001
Uncinate fasciculus
Mean	0.00	NS	−0.01	NS	−0.02	NS	0.01	NS
Max	0.00	NS	0.00	NS	−0.01	NS	0.02	NS

NS: p-values > 0.5 marked as “Not Significant”