Table 2.

Skeletonized Tract Analysis of Dose Sensitivity: Linear mixed model coefficients (percent change per Gy) and p-values

TBSS Tract	FA		MD(× 10−6 mm2/s)		λ‖(× 10−6 mm2/s)		λ⊥(× 10−6 mm2/s)
Dose	Coefficient	p-value	Coefficient	p-value	Coefficient	p-value	Coefficient	p-value
Anterior corona radiata
Mean	0.02	NS	0.02	NS	0.03	NS	0.01	NS
Max	0.01	NS	0.02	NS	0.02	NS	0.01	NS
Anterior limb of internal capsule
Mean	0.06	.331	−0.04	.407	−0.01	NS	−0.08	.131
Max	0.05	.406	−0.03	NS	−0.01	NS	−0.06	.262
Body of corpus callosum
Mean	−0.07	NS	0.01	NS	−0.04	NS	0.11	.089
Max	−0.05	NS	0.01	NS	−0.03	NS	0.08	.034
Cingulum bundle
Mean	−0.29	<.001	0.06	.007	−0.09	<.001	0.23	<.001
Max	−0.20	<.001	0.05	.001	−0.05	<.001	0.17	<.001
Cingulum (parahippocampal)
Mean	0.08	.135	−0.09	<.001	−0.06	.005	−0.13	.001
Max	0.06	.264	−0.07	<.001	−0.04	.044	−0.09	.007
Corticospinal tract
Mean	−0.04	NS	−0.03	NS	−0.03	NS	−0.04	NS
Max	−0.02	NS	−0.01	NS	−0.01	NS	−0.02	NS
External capsule
Mean	0.00	NS	−0.02	NS	−0.02	NS	−0.01	NS
Max	0.01	NS	−0.01	NS	−0.01	NS	−0.01	NS
Fornix (column and body of fornix)
Mean	−0.32	<.001	0.19	<.001	0.03	NS	0.35	<.001
Max	−0.26	<.001	0.16	<.001	0.02	NS	0.29	<.001
Fornix (cres)/Stria terminalis
Mean	−0.06	.303	−0.08	<.001	−0.12	<.001	−0.01	NS
Max	−0.06	.239	−0.06	.002	−0.10	<.001	0.00	NS
Genu of corpus callosum
Mean	−0.01	NS	0.01	NS	0.00	NS	0.02	NS
Max	−0.02	NS	0.02	NS	0.00	NS	0.04	NS
Posterior corona radiate
Mean	0.04	NS	−0.05	.478	−0.03	NS	−0.07	NS
Max	0.04	NS	−0.03	NS	−0.01	NS	−0.05	NS
Posterior limb of internal capsule
Mean	0.10	.002	−0.06	.002	0.00	NS	−0.17	<.001
Max	0.07	.004	−0.04	.024	0.01	NS	−0.12	<.001
Posterior thalamic radiation
Mean	−0.03	NS	−0.06	.087	−0.09	<.001	−0.01	NS
Max	−0.02	NS	−0.04	.235	−0.06	.002	0.00	NS
Retrolenticular part of internal capsule
Mean	0.05	NS	−0.06	.052	−0.03	NS	−0.08	.090
Max	0.04	NS	−0.04	.108	−0.02	NS	−0.07	.123
Sagittal stratum
Mean	0.01	NS	−0.05	.461	−0.05	.136	−0.04	NS
Max	0.01	NS	−0.04	NS	−0.04	.301	−0.02	NS
Splenium
Mean	−0.01	NS	−0.03	NS	−0.04	NS	−0.02	NS
Max	−0.01	NS	−0.01	NS	−0.03	NS	0.01	NS
Superior corona radiate
Mean	0.02	NS	−0.03	NS	−0.01	NS	−0.06	NS
Max	0.03	NS	−0.02	NS	0.01	NS	−0.04	NS
Superior fronto-occipital fasciculus
Mean	0.07	NS	0.03	NS	0.04	NS	0.02	NS
Max	0.07	.161	0.03	NS	0.04	.173	0.02	NS
Superior longitudinal fasciculus
Mean	0.00	NS	−0.06	.048	−0.05	.057	−0.07	NS
Max	0.00	NS	−0.04	.132	−0.03	.221	−0.05	NS
Tapetum
Mean	−0.03	NS	0.08	.001	0.07	.008	0.10	.101
Max	−0.02	NS	0.08	<.001	0.06	.005	0.10	.030
Uncinate fasciculus
Mean	0.02	NS	−0.02	NS	−0.03	NS	0.00	NS
Max	0.02	NS	−0.02	NS	−0.02	NS	0.00	NS

NS: p-values > 0.5 marked as “Not Significant”