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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Bioorg Med Chem Lett. 2017 May 6;27(13):2990–2995. doi: 10.1016/j.bmcl.2017.05.014

Figure 1.

Figure 1

Structures of representative M4 PAMs 1-4, highlighting the optimized rodent in vivo tool M4 PAM, VU0467154 (2), the clinical candidate VU0467485/AZ13713945 (3) and the non-human primate in vivo tool VU0476406 (4).