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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Bioorg Med Chem Lett. 2017 May 6;27(13):2990–2995. doi: 10.1016/j.bmcl.2017.05.014

Figure 4.

Figure 4

Reversal of amphetamine-induced hyperlocomotion in rat (male, Sprague Dawley, n = 8–24 per dose group) by 17j (VU6000918). M4 PAM, control M4 PAM (VU0467154) or vehicle (10% tween-80 90% water [v/v]) was administered orally 30 min after habituation in the chamber, and then 0.75 mg/kg amphetamine or vehicle (100% water) was administered subcutaneously 30 min later (t = 60 min). Total ambulations were measured over the subsequent 1 hr interval (t = 60–120 min) and used to calculate % reversal of AHL for each dose group. Data represent means ± SEM.