Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Population pharmacokinetics of polymyxin B [26].
| Parameter | Observation (range) |
|---|---|
| AUC0–24 (mg hour/L) | 66.9 ± 21.6 (16.4–117) |
| fAUC0–24 (mg hour/L) | 29.2 ± 12.0 (6.05–60.5) |
| Css,avg (mg/L) | 2.79 ± 0.90 (0.68–4.88) |
| Renal Clearance (L/hour) | 0.061 (0.018–0.377) |
| Urinary excretion (%) | 4.04 (0.98–17.4) |
AUC0–24: AUC over a day; Css,avg: average steady-state plasma concentration; fAUC0–24: AUC for unbound fraction.
