Table 3.
Vascular and Valvular Heart Disease in FH Patients Ranked by Age.
| Patient ID | Age (years) | LDL (mg/dL) | Genotype | Homozygous | Apheresis (years) | Previously known CVD | IMT | Vascular disease | Valvular heart disease |
|---|---|---|---|---|---|---|---|---|---|
| 49 | 6 | 603 | LDLR C681X | Yes | 0 | 0.4 | Plaque | ||
| 80 | 7 | 579 | LDLR C681X | Yes | 0 | 0.45 | |||
| 64 | 8 | 439 | LDLRAP Q136X | Yes | 0 | 0.5 | |||
| 22 | 9 | 644 | LDLR C681X | Yes | 2 | 0.6 | |||
| 50 | 10 | 565 | LDLR C681X | No | 0 | 1.45 | CS, plaque | ||
| 61 | 10 | 544 | LDLR C681X | Yes | 0 | 0.45 | CS, plaque | ||
| 77 | 10 | 224 | LDLR C681X | No | 0 | 0.45 | |||
| 7 | 15 | 451 | LDLR C681X | Yes | 9 | 0.55 | mild AS (MG 16, PG 33), ART | ||
| 16 | 15 | 387 | LDLRAP Q136X | Yes | 2 | 0.55 | |||
| 20 | 15 | 500 | LDLR C681X | Yes | 9 | 0.6 | |||
| 2 | 16 | 455 | LDLR C681X | Yes | 8 | 0.55 | mild AR, mild AS (MG 10, PG 27) | ||
| 12 | 17 | 558 | LDLR C681X | Yes | 9 | 0.5 | mild AS (MG 11, PG 26), ART | ||
| 3 | 19 | 652 | LDLR C681X | Yes | 11 | 0.55 | Plaque | mild AR, mild AS (MG 9, PG 24), mild MR | |
| 14 | 19 | 420 | LDLRAP Q136X | Yes | 2 | 0.5 | AoVC | ||
| 6 | 20 | 544 | LDLR C681X | Yes | 12 | 2.1 | Plaque | mild AS (MG 16, PG 34), ART | |
| 11 | 21 | 649 | LDLR I451T | Yes | 10 | 0.5 | mild AS (MG 19, PG 35), mild MR, ART, AoVC | ||
| 15 | 24 | 527 | LDLRAP Q136X | Yes | 2 | 0.95 | Plaque | mild AS (MG 11, PG 24), ART | |
| 8 | 25 | 582 | LDLRAP Q136X | No | 9 | 0.45 | |||
| 26 | 25 | 638 | LDLR C681X | Yes | 7 | 1.3 | CS, plaque | mild AR | |
| 23 | 27 | 541 | LDLR C681X | Yes | 13 | 1.8 | Plaque | mild AR, moderate AS (MG 34, PG 64), AoVC, ART | |
| 67 | 28 | 390 | LDLRAP Q136X | Yes | 0 | MI | 0.45 | mild AS, ART | |
| 21 | 29 | 495 | LDLR C681X | Yes | 5 | 1.05 | mild AR, ART | ||
| 75 | 30 | 219 | LDLR C681X | No | 10 | Stroke | 0.5 | ||
| 25 | 31 | 545 | LDLR C681X | Yes | 8 | 2.05 | CS, plaque | mild AR, moderate AS (MG 40, PG 64), mild MR, AoVC, CMV, ART | |
| 66 | 31 | 264 | LDLRAP Q136X | Yes | 0 | 0.5 | AoVC | ||
| 68 | 31 | 245 | LDLRAP Q136X | Yes | 0 | 1.5 | CS, plaque | mild MR, AoVC | |
| 17 | 32 | 505 | LDLRAP Q136X | Yes | 10 | 0.55 | AOVC | ||
| 1 | 42 | 413 | LDLR C681X | Yes | 9 | MI, CEA | 2.1 | CS, plaque | mild AR, moderate AS (MG 40, PG 64), moderate MR, AoVC, ART |
| 30 | 46 | 348 | LDLR C681X | Yes | 6 | 0.8 | CS, plaque | AoVC, ART | |
| 29 | 57 | 202 | LDLR C681X | Yes | 16 | MI | 0.5 | Plaque | mild AS (MG 20, PG 36), AoVC, ART |
| 76 | 57 | 158 | LDLR C681X | No | 7 | MI, CEA, stroke | 0.5 | CS | mild AS, AoVC, CMV, ART |
| 13 | 65 | 169 | LDLR C681X | No | 10 | MI, CEA | 2 | CS, plaque | mild AR, moderate MR, AoVC, CMV, ART |
CEA: carotid endarterectomy; MI: myocardial infarction; CS: carotid stenosis; AS: aortic stenosis; ART: aortic root thickening; AR: aortic regurgitation; MR: mitral regurgitation; AoVC: aortic valve calcification; CMV: calcified mitral valve; MG: mean gradient (in mmHg); PG: peak gradient (in mmHg).