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. 2017 Jul 12;37(4):BSR20170805. doi: 10.1042/BSR20170805

Figure 5. TGF-β inhibitor reverses TRIM25 function on stimulating proliferation and invasion of CRCs.

Figure 5

(A) The transwell invasion assay was performed on the HCT116 cells transfected with either control plasmid (CON) or TRIM25 overexpressing plasmid (TRIM25). The transwell chamber contained either DMSO or 10 μM TGF-β inhibitor (SB-431542). (B) In vitro CCK-8 proliferation assay was performed to determine the proliferation rate of HCT116 cells transfected with either CON or TRIM25, and treated with either DMSO or 10 μM TGF-β inhibitor (SB-431542). **P<0.001, ***P<0.0001.