Figure 5. NMN reduces daily energy expenditure in the FXN-KO mouse in a SIRT3-dependent manner.

(A) Energy expenditure, (B) fat oxidation, (C) carbohydrate oxidation, (D) oxygen consumption (VO₂) and carbon dioxide production (VCO₂), and (E) respiratory exchange ratio (RER). Values are means ± SEM (n = 3–6 mice/group). *P < 0.05, difference from saline-treated WT as determined by two-way ANOVA for 8 groups (4 genotypes, 2 treatment) and Bonferroni correction. W, WT; F, FXN-KO; S, SIRT3-KO; D, dKO; subscript S, saline; and subscript N, NMN.