Table 3. Hazard ratio (95% confidence interval) for acid-base parameters and risk of ESRD or 50% decline in eGFR over follow up stratified by diabetes mellitus.

Quartile of Net Acid Excretion	Unadjusted†	+Demographic	+ CVD	+eGFR/albuminuria	+ ucreatinine/BMI
Participants without Diabetes (n=459; 107 events)
Q1 (<20.4 mEq/d)	1.0	1.0	1.0	1.0	1.0
Q2 (20.4–30.7 mEq/d)	1.03 (0.62, 1.70)	0.93 (0.56, 1.55)	0.95 (0.57, 1.57)	1.24 (0.74, 2.07)	1.29 (0.77, 2.16)
Q3 (30.8–41.8 mEq/d)	0.84 (0.50, 1.43)	0.83 (0.49, 1.43)	0.85 (0.50, 1.46)	0.93 (0.54, 1.59)	1.01 (0.58, 1.75)
Q4 (≥41.9 mEq/d)	0.64 (0.36, 1.13)	0.58 (0.33, 1.04)	0.58 (0.32, 1.03)	0.84 (0.46, 1.52)	0.99 (0.51, 1.92)
Continuous per 10 mEq/d higher	0.90 (0.79, 1.02)	0.88 (0.78, 1.00)	0.88 (0.78, 1.00)	0.98 (0.85, 1.12)	1.04 (0.89, 1.22)
P*	0.11	0.06	0.05	0.74	0.64
Participants with Diabetes (n=457; 189 events)
Q1 (<20.4 mEq/d)	1.0	1.0	1.0	1.0	1.0
Q2 (20.4–30.7 mEq/d)	0.96 (0.64, 1.44)	1.00 (0.67, 1.49)	1.05 (0.70, 1.58)	0.81 (0.54, 1.22)	0.89 (0.57, 1.33)
Q3 (30.8–41.8 mEq/d)	0.81 (0.55, 1.18)	0.83 (0.57, 1.23)	0.87(0.59, 1.28)	0.64 (0.43, 0.96)	0.76 (0.50, 1.16)
Q4 (≥41.9 mEq/d)	0.50 (0.33, 0.75)	0.51 (0.33, 0.78)	0.52 (0.34, 0.81)	0.51 (0.33, 0.80)	0.66 (0.40, 1.08)
Continuous per 10 mEq/d higher	0.84 (0.78, 0.92)	0.84 (0.77, 0.92)	0.85 (0.78, 0.93)	0.84 (0.76, 0.93)	0.88 (0.80, 0.98)
P*	<0.01	<0.01	<0.01	<0.01	0.03

^*p is for linear trend derived from a continuous linear model of net acid excretion and outcome

^†Models are sequentially adjusted for demographics (age, sex, race/ethnicity); followed by history of cardiovascular disease (CVD); followed by eGFR and albuminuria (log 24-hour urine albumin); followed by 24 hour urine creatinine (ucreatinine) and body mass index (BMI)