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Agrin signaling and YAP in neuromuscular junction formation (NMJ) and liver cancer development. A, Agrin is released from motor nerve terminals to induce AChR clusters and to direct NMJ formation. YAP and β-catenin in muscles regulate both post- and pre-synaptic differentiation. B, Agrin serves as a mechanotransduction signal to activate YAP by suppressing the Hippo pathway and by stimulating integrin-focal adhesion (FA) and thus to promote liver cancer development.
