Table 2.

Univariate and multivariate analyses of OS

Characteristics		Univariate		Multivariate
		HR (95% CI)	P	HR (95% CI)	P
Age	≥ 57 years	1		1
	< 57 years	0.6 (0.4–0.7)	0.0001*	0.5 (0.4–0.7)	< 0.0001*
Sex	Male	1		-
	Female	0.96 (0.7–1.3)	0.790	-
Race	Caucasian	1		-
	Others	1.1 (0.8–1.5)	0.495	-
Site	Oropharynx	1		1
	Oral Cavity	1.1 (0.8–1.6)		1.1 (0.8–1.6)
	Larynx	0.97 (0.7–1.4)		0.9(0.6–1.4)
	Hypopharynx	1.5 (1–2.3)	0.069	1.1(0.8–1.8)	0.410
T stage	T1-T2	1		-
	T3-T4	1.0 (0.8–1.4)	0.798	-
N stage	N1-N3	1		1
	N0	0.7 (0.6–0.96)	0.024*	0.91 (0.7–1.2)	0.463
ECE	Positive	1		1
	Negative	0.6 (0.5–0.8)	0.0002*	0.9 (0.6–1.2)	0.026*
Margins status	Positive	1		1
	Others	0.5 (0.4–0.8)	0.007*	0.5 (0.3–0.85)	0.011*
Nerve invasion	Negative	1		1
	Others	1.2 (0.9–1.6)	0.213	1.2 (0.8–1.6)	0.385
Number of +ve nodes	≥2	1		1
	0–1	0.5 (0.4–0.7)	< 0.0001*	0.7 (1.3–3.6)	0.098
Number of nodal groups	≥2	1		1
	0–1	0.5 (0.4–0.7)	< 0.0001*	0.8 (0.5–1.3)	0.391
Direct invasion	Yes	1		1
	No	0.8 (0.6–1.1)	0.0842	1.0 (0.7–1.6)	0.655
primary RT BED	continuous		0.0911		0.757
Neck RT BED	continuous		< 0.0001*		0.097
Package Time	≥85 days	1		1
	< 85 days	0.6 (0.5–0.8)	0.0003*	0.7 (0.5–0.9)	0.003*