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Statistical moment analysis on the profiles of vaginal retention percentage vs. time in mice.
| Formulation | Pharmacokinetic parametera |
Ratio of AUC(0–t)b |
|
|---|---|---|---|
| MRT(0–t) (h) | AUC(0–t) (%·h) | Intravaginal F (%) | |
| GEL1 | 2.29 ± 0.21 | 136.1 ± 43.8 | 648.1 |
| GEL2 | 2.23 ± 0.46 | 140.6 ± 10.3 | 669.5 |
| Solution | 0.22 ± 0.01 | 21.0 ± 1.6 | – |
Data are mean±S.D., n = 6.
The prolonged retention was evaluated by the ratio of AUC(0–t) between the hydrogel and the solution.
