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Binding mode of compounds 4e (cyan) and 4j (magenta) into NS2B/NS3 serine protease active site. Compound 4e formed five hydrogen bonds (yellow dotted lines) with His51 (2.9 Å), Pro132 (2.8 Å), Ser135 (2.8 Å), Gly153 (2.5 Å) and Arg54 (3.1 Å) whereas compound 4j formed six hydrogen bonds (yellow dotted lines) with His51 (2.9 Å), Pro132 (2.8 Å), Ser135 (2.8 Å), Gly153 (2.5 Å), Arg54 (2.8 Å) and Trp50 (3.1 Å).
