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. 2017 May 29;6(8):819–832. doi: 10.1016/j.molmet.2017.05.011

Figure 6.

Figure 6

Manipulations to skeletal muscle NAD+biosynthesis pathways. (A) NRK1KO, (B) NRK2KO, and (C) NRK double KO (DKO) primary myotubes supplemented with 0.5 mM NAD+ precursors for 24 h (left) and corresponding primary myotubes supplemented with 0.5 mM NAD+ precursors for 24 h following 1 μM FK866 mediated NAMPT inhibition (right). For clarity, all data is presented as percent change in NAD+ compared to DMSO only control (100%) (all groups n = 4 and significance determined between WT and corresponding KO from actual NAD+ content by two-way ANOVA using Bonferroni's post-test).