Figure 2.
Concentration-dependent N-acetylation of INH in cryoplateable human hepatocytes. Cryoplateable human hepatocytes with a rapid NAT2 genotype were plated on collagen coated 12-well plate and allowed to attach. After 24 h plating media was removed and replaced with media containing (0–200 µmol/L) INH for 24 h. The amount of acetyl-INH produced was measured in the media. Each data point is mean ± S.E.M. for three independent measurements. Data shows concentration-dependent increase in the production of INH.