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. 2017 Jun 7;7(4):517–522. doi: 10.1016/j.apsb.2017.05.003

Figure 3.

Fig. 3

Time-dependent N-acetylation of INH in cryoplateable human hepatocytes. Cryoplateable human hepatocytes with a rapid NAT2 genotype were plated on collagen coated 12-well plate and allowed to attach. After 24 h plating media was removed and replaced with media containing 12.5 or 100 µmol/L INH. Cells were incubated with media containing INH for 0–48 h. The amount of acetyl-INH produced was measured in the media. Each data point is mean ± S.E.M. for three independent measurements. Data shows R-squared for goodness of fit for the time-dependent increase in the production of acetylated-INH was 0.9612 and 0.9599 for 12.5 and 100 µmol/L, respectively.