Table 1.

Isoniazid (INH) and N-(4-aminobenzoyl)-L-glutamic acid (ABG) N-acetyltransferase activities in vitro in human cryopreserved human hepatocyte samples.

Sample ID	NAT2 genoytpe	Deduced NAT2 phenotype	Gender	Ethnicity	INH N-acetyltransferase activitya	ABG N-acetyltransferase activitya
FLA	NAT2*4/*4	Rapid	Female	Caucasian	0.361	0.494
HWG	NAT2*4/*4	Rapid	Male	Caucasian	0.183	0.358
GPM	NAT2*4/*4	Rapid	Male	Hispanic	0.155	0.388
FXA	NAT2*4/*4	Rapid	Female	Hispanic	0.141	0.303
XUA	NAT2*4/*13	Rapid	Female	Caucasian	0.084	0.311
VHU	NAT2*4/*5B	Intermediate	Female	African	0.075	0.311
UFN	NAT2*4/*5B	Intermediate	Male	Caucasian	0.124	0.291
ZCA	NAT2*4/*5B	Intermediate	Female	Caucasian	0.051	0.256
ZQM	NAT2*4/*5A	Intermediate	Female	Caucasian	0.023	0.261
OJE	NAT2*4/*6A	Intermediate	Female	Caucasian	0.057	0.446
DVR	NAT2*5B/*5B	Slow	Female	Caucasian	0.042	0.329
PFM	NAT2*5B/*5B	Slow	Male	Caucasian	0.008	0.617
ZFB	NAT2*5B/*6A	Slow	Female	Caucasian	0.044	0.413
MFB	NAT2*5A/*6A	Slow	Male	Hispanic	0.005	0.438
XMM	NAT2*6A/*6A	Slow	Male	Caucasian	0.001	0.673

Mean ± S.E.M. for rapid, intermediate, and slow NAT2 phenotypes are illustrated in Fig. 1.

^aINH and ABG N-acetyltransferase activities in nmol/min/mg protein.