Table 2.

Acetyl-INH levels in human cryopreserved human hepatocytes.

Sample ID	NAT2 genotype	Deduced NAT2 phenotype	Gender	Ethnicity	Acetyl-INH levela
					12.5 µmol/L INH	100 µmol/L INH
FWK	NAT2*4/*4	Rapid	Female	Caucasian	26.2	60.7
ZFK	NAT2*4/*4	Rapid	Male	Caucasian	33.4	72.8
YXZ	NAT2*4/*4	Rapid	Male	Hispanic	18.3	48.6
JZG	NAT2*4/*4	Rapid	Male	Hispanic	30.1	69.8
FAO	NAT2*4/*4	Rapid	Female	African	18.3	51.6
ZFR	NAT2*4/*5B	Intermediate	Male	Caucasian	15.3	41.9
TUG	NAT2*4/*5B	Intermediate	Male	Caucasian	22.5	60.1
HUG	NAT2*4/*5B	Intermediate	Female	Caucasian	10.2	33.5
ASQ	NAT2*4/*5A	Intermediate	Female	Caucasian	19.2	38.3
NIQ	NAT2*4/*6A	Intermediate	Female	Caucasian	12.1	35.6
UFP	NAT2*5B/*6A	Slow	Female	Caucasian	0.21	7.00
DOO	NAT2*5B/*6A	Slow	Male	Caucasian	1.70	13.20
DNB	NAT2*5B/*6A	Slow	Male	Caucasian	0.17	2.00
YNS	NAT2*5A/*6A	Slow	Male	Hispanic	0.52	8.05
UNF	NAT2*6A/*6A	Slow	Male	African	1.10	0.85

Hepatocyte samples were incubated 24 h with 12.5 or 100 µmol/L INH.

Mean ± S.E.M. for rapid, intermediate, and slow NAT2 phenotypes are illustrated in Fig. 4.

^aAcetyl-INH levels are nmoles acetyl-INH/24 h/million cells.