Table 1.
Associations of activating gene mutation status with clinicopathologic features
| Factor |
Total N |
WT | GNAQ | GNA11 | NRAS | CYSLTR2 | BRAF | P-value | |
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Median (range) | Median (range) | Median (range) | Median (range) | Median (range) | Median (range) | ||||
|
| |||||||||
| Age | 103 | 41 (17–76) | 53 (7–91) | 67 (22–85) | 70 (31–83) | 78 (73–81) | a | 0.054 | |
| N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | ||||
| Sex | |||||||||
| Female | 60 | 14 (23) | 33 (55) | 9 (15) | 3 (5) | 0 | 1 (2) | 0.06 | |
| Male | 43 | 4 (9) | 28 (65) | 8 (19) | 0 | 3 (7) | 0 | ||
| Anatomic site | |||||||||
| Head/neck | 26 | 6 (23) | 13 (50) | 5 (19) | 0 | 2 (8) | 0 | 0.08 | |
| Upper limbs | 27 | 3 (11) | 19 (70) | 3 (11) | 0 | 1 (4) | 1 (4) | ||
| Trunk | 28 | 7 (25) | 19 (68) | 1 (4) | 1 (4) | 0 | 0 | ||
| Lower limbs | 17 | 1 (6) | 8 (47) | 7 (41) | 1 (6) | 0 | 0 | ||
| Missing data | 5 | 1 | 2 | 1 | 0 | 1 | 0 | ||
| Subtype | |||||||||
| Common BN | 81 | 13 (16) | 48 (59) | 15 (19) | 2 (3) | 3 (4) | 0 | 0.29 | |
| Cellular BNb | 22 | 5 (23) | 13 (59) | 2(9) | 1 (5) | 0 | 1 (5) | ||
| Depth | |||||||||
| Upper dermis | 11 | 3 (27) | 4 (36) | 3 (27) | 0 | 1 (9) | 0 | 0.28 | |
| Lower dermis | 64 | 15 (23) | 37 (58) | 8 (13) | 2 (3) | 1 (2) | 1 (2) | ||
| Subcutis | 20 | 0 | 16 (80) | 3 (15) | 0 | 1 (5) | 0 | ||
| Missing data | 8 | 0 | 5 | 3 | 0 | 0 | 0 | ||
| Cell type | |||||||||
| Spindle | 77 | 13 (17) | 48 (62) | 12 (16) | 1 (1) | 3 (4) | 0 | 0.02 | |
| Epithelioidc | 7 | 1 (14) | 5 (71) | 0 | 0 | 0 | 1 (14) | ||
| Mixed | 10 | 4 (40) | 3 (30) | 2 (20) | 1 (10) | 0 | 0 | ||
| Missing data | 9 | 0 | 5 | 3 | 1 | 0 | 0 | ||
| Pigmentation | |||||||||
| Absent | 9 | 2 (22) | 6 (67) | 0 | 0 | 1 (11) | 0 | 0.06 | |
| Mild-moderate | 70 | 15 (21) | 42 (60) | 10 (14) | 0 | 2 (3) | 1 (1) | ||
| Marked | 15 | 1 (7) | 8 (53) | 4 (27) | 2 (13) | 0 | 0 | ||
| Missing data | 9 | 0 | 5 | 3 | 1 | 0 | 0 | ||
a
1 patient, age 46 years.
b
All tumors demonstrating a cellular component
c
Epithelioid signifies cell morphology with oval to rounded (rather than elongated/spindle) nuclei. Mixed refers to nevi having both a spindle cell and epithelioid component.
WT, wild-type for all tested genes; epith., epithelioid.