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. Author manuscript; available in PMC: 2017 Jul 20.
Published in final edited form as: Hum Mutat. 2016 Dec 9;38(2):193–203. doi: 10.1002/humu.23148

Figure 1.

Figure 1

Key features of the human RECQ helicase genes and proteins. Each of the five human RECQ helicases is presented in a row. The official HGNC gene symbol is followed by chromosomal location; a schematic representation of the protein open reading frame aligned on the RECQ helicase consensus/ATPase domain (filled center segment in each protein) and indicating the locations of additional functional domains: WRN exonuclease, RQC (RECQ consensus), HRDC (helicase and RNaseD C-terminal), and RECQL4 Sld2-like/mitochondrial-targeting domains, as well as the position of nuclear-targeting sequences. The size of each mature protein is listed after each protein model in amino acid residues, followed by a summary of biochemically verified catalytic activities for each protein.