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. 2017 Jun 7;6(8):909–921. doi: 10.1016/j.molmet.2017.06.002

Figure 4.

Figure 4

5-HT activates PPG fibers directly and this is dependent on influx of extracellular Ca2+. (A) Removal of extracellular Ca2+ attenuates the response to 20 μM 5-HT. Left panel: Traces showing changes in intracellular Ca2+ with individual fibers shown in gray and the average trace in red (n = 16 dendrites). Right panel: Median AUC in response to 20 μM 5-HT in the presence and absence of extracellular Ca2+ (n = 28 dendrites (3 mice); Wilcoxon test: p < 0.0001). (B) Left panel: Traces showing the response to 20 μM 5-HT in the presence or absence of TTX (0.5 μM) and DNQX (20 μM) (n = 8 dendrites). Right panel: Median AUC during the response to 20 μM 5-HT in the absence (white box) or presence (gray box) of TTX and DNQX (n = 55 dendrites (4 mice)). Wilcoxon test: p = 0.56 n.s.: not significant.