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. 2017 Jun 20;6(8):897–908. doi: 10.1016/j.molmet.2017.06.008

Figure 5.

Figure 5

Deletion of RAGE and ALCAM genes improves metabolic symptoms induced by a HCHF diet. (A & B) Daily caloric intake (in wk10) and weekly body weight gain of chow or HCHF diet-fed WT versus RAGE-ALCAM−/− mice (n = 6–11 per group); for weekly BW gain, from wk5 on, WT and RAGE-ALCAM−/− mice have less BW gain in chow than in HCHF; From wk1 to wk4 and from wk9 to wk16, there are significant effect of genotype on BW gain on HCHF. (C) Body composition of WT versus RAGE-ALCAM−/− mice fed HCHF diet (n = 4–8 per group). (D) Glucose tolerance of WT versus RAGE-ALCAM−/− mice fed chow or HCHF diet (n = 5–7 per group). (E) Glucose tolerance of RAGE-ALCAM−/− mice fed chow or HCHF diet (n = 5–7 per group). Data are presented as means ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001. Asterisks indicate significance between WT and RAGE-ALCAM−/− mice. Two-way ANOVA followed by Bonferroni multiple comparisons for post-hoc analysis was performed to detect significant interactions between genotype and diet on daily caloric intake, BW gain and body mass. Two-tailed Student's t test was performed between each time point in D and E, to detect the effect of genotype on glucose tolerance on chow or HCHF diet.