Table 4.

Multivariate Analyzes of the Effect of First Pregnancy After Breast Cancer on Risk of Recurrence and Death by Stage at Diagnosis

	Total no. of cases	Unadjusted HR (95% CI)	Adjusted model* HR (95% CI)
Recurrence
Regional disease (positive axillary nodes)
No subsequent pregnancy	98	1	1
Subsequent pregnancy	28	1.3 (0.7,2.6)	1.6 (0.7,3.4)
Local disease†
No subsequent pregnancy	231	1	1
Subsequent pregnancy	74	1.0 (0.5, 1.7)	1.1 (0.5, 2.0)
Death
Regional disease (positive axillary nodes)
No subsequent pregnancy	107	1	1
Subsequent pregnancy	31	1.0 (0.4, 2.1)	1.3 (0.5, 3.4)
Local disease†
No subsequent pregnancy	237	1	1
Subsequent pregnancy	76	0.6 (0.3, 1.4)	0.8 (0.4, 2.0)

^*Adjusted for age at diagnosis (continuous), chemotherapy (yes/no), radiation therapy (yes/no).

^†Includes local disease and DCIS.

DCIS, ductal carcinoma in situ.