Table 2.

Structural variability in BBB breakdown to [131]-Iodine induced by methamphetamine in intact rats and animals exposed to nanoparticles treatment

Brain regions	METH			METH+SiO2			METH+AgNP
	4°C	21°C	34°C	4°C	21°C	34°C	4°C	21°C	34°C
1. Occipital cortex	0.23±0.04	0.86±0.04	1.12±0.08	0.89±0.09*	1.34±0.10*	1.78±0.12*	0.76±0.09*	0.98±0.06	1.48±0.06*
2. Parietal cortex	0.18±0.03	0.89±0.04	1.33±0.10	0.96±0.08*	1.28±0.08*	1.89±0.13*	0.88±0.08*	1.02±0.09	1.39±0.07
3. Cingulate cortex	0.17±0.04	0.98±0.10	1.45±0.12	0.98±0.05*	1.56±0.13*	1.88±0.09*	0.90±0.05*	1.17±0.10	1.65±0.12
4. Temporal cortex	0.20±0.07	0.76±0.07	1.21±0.08	0.88±0.05*	1.48±0.08*	1.95±0.05*	0.87±0.03*	1.23±0.08*	1.76±0.14*
5. Frontal cortex	0.24±0.04	0.90±0.12	1.34±0.06	0.87±0.10*	1.67±0.14*	2.04±0.16*	0.78±0.04*	1.34±0.06*	1.88±0.12*
6. Piriform cortex	0.13±0.02	0.78±0.05	1.33±0.03	0.96±0.09*	1.55±0.06*	2.21±0.14*	0.89±0.10*	1.32±0.08*	1.90±0.14*
7. Hippocampus	0.26±0.08	0.88±0.10	1.38±0.08	1.08±0.10*	1.76±0.14*	2.06±0.06*	0.98±0.09*	1.44±0.12*	1.76±0.14*
8. Thalamus	0.28±0.09	0.67±0.04	0.98±0.04	0.98±0.10*	1.66±0.05*	2.14±0.12*	0.89±0.10*	1.56±0.12*	1.90±0.13*
9. Hypothalamus	0.26±0.04	0.70±0.03	1.21±0.12	0.89±0.12*	1.56±0.15*	2.12±0.08*	0.82±0.12*	1.32±0.08*	1.88±0.08*
10. Cerebellum	0.11±0.04	0.89±0.08	1.54±0.05	1.21±0.08*	1.89±0.08*	2.23±0.08*	0.99±0.12*	1.45±0.13*	1.96±0.15*
11, Colliculi	0.22±0.04	0.87±0.10	1.32±0.08	0.90±0.12*	1.76±0.06*	2.14±0.12*	0.78±0.07*	1.22±0.06*	1.79±0.12*
12. Brain Stem	0.15±0.05	0.45±0.05	0.56±0.04	0.78±0.05*	0.98±0.08*	1.14±0.08*	0.68±0.07*	0.86±0.05*	0.97±0.08*

Values are mean±SEM obtained from 5 to 8 rats at each point. Asterisks show statistically significant differences between METH treatment at different ambient temperatures with and without additional exposure to nanoparticles (*, p<0.05). METH 4°C values are quite similar to that seen in saline control.