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Gαq-KO inhibits in vitro Th17 differentiation. (a–f) Naive CD4+ T cells from WT and Gαq-KO mice were induced to differentiate into Th1 (a, b) or Th17 (d, e) cells in vitro. Antigen-specific Th1 and Th17 responses were measured by ELISA for IFN-γ and IL-17A production in the supernatant (c, f). The data are expressed as the mean±s.e.m. (n=3), ***P<0.001 versus WT.
