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. 2017 Feb 20;14(6):557–567. doi: 10.1038/cmi.2016.65

Figure 6.

Figure 6

The downstream pathways involved in Gαq-mediated regulation of IL-6 production in DCs. BMDCs were generated in vitro and stimulated with LPS (1 μg/ml) or not for 24 h in the presence of various pathway inhibitors, and IL-6 production was measured by ELISA. (a-b) The effect of the PLCβ inhibitor U73122 and the PKC inhibitor Ro 31-8220 (a) and the MAPK inhibitors SB203580, U0126 and SP600125 (b) on IL-6 production from BMDCs. (c) The working model that deficiency of Gαq ameliorates EAE through impaired DC/IL-6 production and Th17 differentiation. The data are expressed as the mean±s.e.m. (n=3), *P<0.05 versus DCs treated without LPS and inhibitors; #P<0.05, ##P<0.01, ###P<0.001 versus DCs treated with LPS alone.