Table 3. Association of identified mutations with clinicopathologic features.
| Mutations not identified (n=39) | Mutations identified (n=27) | ||
|---|---|---|---|
| Characteristic | N (%)a | N (%)a | P-value |
| Age (mean±s.d.) | 65.2±12.6 years | 61.3±13.4 years | 0.23 |
| Sex | 0.20 | ||
| Female | 17 (44%) | 16 (59%) | |
| Male | 22 (56%) | 11 (41%) | |
| Smoking | 0.14 | ||
| Current/former | 19 (49%) | 9 (33%) | |
| Never | 20 (51%) | 18 (67%) | |
| Site | 0.09 | ||
| Nasal cavity | 34 (87%) | 8 (30%) | |
| Paranasal sinuses | 5 (13%) | 19 (70%) | |
| T classification | 0.76 | ||
| 3 | 22 (56%) | 13 (48%) | |
| 4a | 13 (33%) | 10 (37%) | |
| 4b | 4 (10%) | 4 (15%) | |
| N classification | 0.36 | ||
| N0 | 36 (92%) | 23 (85%) | |
| N+ | 3 (8%) | 4 (15%) | |
| Mitosis rate | 0.01 | ||
| <1 | 27 (69%) | 10 (37%) | |
| ⩾1 | 12 (31%) | 17 (63%) | |
| Ulceration | 0.59 | ||
| Present | 27 (69%) | 17 (63%) | |
| Absent | 12 (31%) | 10 (37%) | |
| Cell morphology | 0.43 | ||
| Pagetoid | 8 (21%) | 6 (22%) | |
| Epithelioid | 7 (18%) | 7 (25%) | |
| Spindled | 7 (18%) | 9 (33%) | |
| Rhabdoid | 8 (21%) | 4 (15%) | |
| Undifferentiated (small cell) | 13 (33%) | 9 (33%) | |
| Bone invasion | 0.35 | ||
| Absent | 33 (85%) | 20 (74%) | |
| Present | 6 (15%) | 7 (26%) | |
| Treatment | 0.88 | ||
| Surgery | 18 (46%) | 12 (44%) | |
| Surgery and radiation | 18 (46%) | 12 (44%) | |
| Surgery and chemoradiation | 3 (8%) | 3 (12%) |
a
Unless otherwise indicated.