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RSPO2 and RSPO4 stimulate Wnt/β-catenin pathway activity in MDA-MB-468 cells. (A) Effect of RSPO2, RSPO4 and/or Wnt3a on the expression of phosphorylated LRP (phospho-LRP) and active β-catenin. (B) Effect of RSPO2, RSPO4, and/or Wnt3a on Wnt/β-catenin transcriptional activity. (C) Effect of RSPO2, RSPO4, and/or Wnt3a on the expression of Axin2 and DKK1. CM: conditioning medium, W: Wnt3a, R2: RSPO2, R4: RSPO4, *: indicates P⩽0.05 vs control (CM: 0).
