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. 2017 Mar 1;42(8):1619–1629. doi: 10.1038/npp.2017.21

Figure 2.

Figure 2

Ro 61-8048 blocks reinstatement of extinguished nicotine seeking in rats. Ro 61-8048 (100 mg/kg, i.p., 40 min before the session) blocked the reinstating effect of combined nicotine priming (0.2 mg/kg, s.c., 10 min before the session) and reintroduction of response-contingent presentation of visual cues that were previously associated with nicotine injections. PNU120596 (1 mg/kg, i.p., 60 min before the session) failed to block the effect of Ro 61-8048 on reinstatement. Responses in active and inactive holes per 2 h sessions are shown. Bars represent means±SEM (n=10 in all groups). *Significantly different from vehicle session (saline prime and no cues), Ro 100, PNU, and Ro+Nic (active responding); $significantly different from the vehicle session; #significant difference between active and inactive responding, Tukey’s test, $p<0.05; ##p<0.01; *** or ###p<0.001. Nic, nicotine; Ro, Ro 61-8048; PNU, PNU120596.