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. Author manuscript; available in PMC: 2017 Jul 20.
Published in final edited form as: Pathology. 2016 Apr 23;48(4):291–302. doi: 10.1016/j.pathol.2016.02.015

Fig. 4.

Fig. 4

Vulvar intraepithelial neoplasia (VIN), immunohistochemical features. p16 with (A) diffuse strong block-like staining in VIN 3; (B) patchy staining in condyloma acuminatum; (C) negative in dVIN. p53 shows (D) weak patchy staining in normal skin, (E) increased basal staining in squamous cell hyperplasia, and (F) increased basal and parabasal staining in dVIN. Ki-67 shows (G) full thickness staining in VIN 3, and (H) increased basal and parabasal staining in dVIN. (I) normal skin shows no Ki-67 staining in the basal layer (arrows).