Skip to main content
. Author manuscript; available in PMC: 2017 Jul 20.
Published in final edited form as: Pathology. 2016 Apr 23;48(4):291–302. doi: 10.1016/j.pathol.2016.02.015

Table 1.

Major classification schemes proposed for squamous precursor lesions of the vulva over time.

1958 1976 ISSVD 1986 ISSVD 2004 ISSVDa
2003 WHOa 		2005 Bethesda-like 2012 LAST
2014 WHO
2015 ISSVD
CIS Mild atypia VIN I –a LG-VIL

  • Condyloma

  • VIN 1

 LSIL

  • VIN 1

  • Condyloma

  • Mild dysplasia

  • Koilocytic atypia
Moderate atypia VIN II uVIN

  • VIN 2

  • VIN 3

 HG-VIL

  • VIN 2–3

  • dVIN

 HSIL

  • VIN 2–3

  • Moderate/severe dysplasia

  • Bowen disease

  • Bowenoid dysplasia

  • CIS
Severe atypia or CIS VIN III, severe atypia or VIN III, CIS
– – VIN III, differentiated type dVIN dVINb

CIS, carcinoma in situ; dVIN, differentiated type VIN; HG-VIL, high-grade vulvar intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion; ISSVD, International Society for the Study of Vulvovaginal Disease; LAST, Lower Anogenital Squamous Terminology; LG-VIL, low-grade vulvar intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; uVIN, usual type VIN; VIN, vulvar intraepithelial neoplasia; WHO, World Health Organization.

a

The 2004 ISSVD no longer recognised VIN 1 but the 2003 WHO retained the designation.

b

dVIN not included in the LAST guidelines.