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. 2017 Apr 4;27(7):916–932. doi: 10.1038/cr.2017.51

Figure 3.

Figure 3

Extracellular histone promotes pancreatic tumorigenesis in KCH mice. (A) H3 Ab or IL-6 Ab treatment (10 mg/kg i.p., twice per week, started at four weeks of age for four weeks) prolonged survival in KCH mice at 12 weeks of age (n = 10 mice/treatment, **P < 0.01, ***P < 0.001, log-rank test). The median survival of untreated, IgG-treated, H3 Ab-treated, and IL-6 treated KCH mice were nine, nine, 12, and 12 weeks, respectively, in this setting. (B-I) In parallel, pancreatic lesion formation (B), incidence of tumor metastasis/invasion (C), serum IL-6 level (D), percentage of tumor infiltration of macrophages (E) and neutrophils (F), and relative expression of p-ERK1/2 (G), p-AKT (H), and p-STAT3 (I) in the pancreas were assayed. Graphs show means ± sem, *P < 0.05, **P < 0.01, ***P < 0.001 (n = 5 mice/treatment, unpaired t-test).