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. 2017 Jul 20;13(7):e1005513. doi: 10.1371/journal.pcbi.1005513

Table 2. The lumped reactions generated for deoxynucleoside triphosphate dTTP.

BBB LUMPED REACTIONS YIELD
dTTP 6 ATP + FOR + H + 4 NADPH + 2 NH4 + OAA + Q8 + R5P ->
6 ADP + DTTP + 3 H2O + 4 NADP + 4 PI + Q8H2
0.74
6 ATP + FOR + H + MQN8 + 4 NADPH + 2 NH4 + OAA + R5P ->
6 ADP + DTTP + 3 H2O + MQL8 + 4 NADP + 4 PI
0.73
8 ATP + FOR + 4 NADPH + 2 NH4 + OAA + Q8 + R5P ->
8 ADP + DTTP + H + H2O + 4 NADP + 6 PI + Q8H2
0.71
8 ATP + FOR + MQN8 + 4 NADPH + 2 NH4 + OAA + R5P ->
8 ADP + DTTP + H + H2O + MQL8 + 4 NADP + 6 PI
0.70
6 ATP + COA + FOR + H + 3 NADPH + 2 NH4 + OAA + PYR + Q8 + R5P ->
ACCOA + 6 ADP + CO2 + DTTP + 3 H2O + 3 NADP + 4 PI + Q8H2
0.66
6 ATP + COA + FOR + H + MQN8 + 3 NADPH + 2 NH4 + OAA + PYR + R5P ->
ACCOA + 6 ADP + CO2 + DTTP + 3 H2O + MQL8 + 3 NADP + 4 PI
0.66
8 ATP + COA + FOR + 3 NADPH + 2 NH4 + OAA + PYR + Q8 + R5P ->
ACCOA + 8 ADP + CO2 + DTTP + H + H2O + 3 NADP + 6 PI + Q8H2
0.64
8 ATP + COA + FOR + MQN8 + 3 NADPH + 2 NH4 + OAA + PYR + R5P ->
ACCOA + 8 ADP + CO2 + DTTP + H + H2O + MQL8 + 3 NADP + 6 PI
0.63
6 ATP + FOR + FUM + H + 4 NADPH + 2 NH4 + OAA + R5P ->
6 ADP + DTTP + 3 H2O + 4 NADP + 4 PI + SUCC
0.59
8 ATP + FOR + FUM + 4 NADPH + 2 NH4 + OAA + R5P ->
8 ADP + DTTP + H + H2O + 4 NADP + 6 PI + SUCC
0.57
6 ATP + COA + FOR + FUM + H + 3 NADPH + 2 NH4 + OAA + PYR + R5P ->
ACCOA + 6 ADP + CO2 + DTTP + 3 H2O + 3 NADP + 4 PI + SUCC
0.54
8 ATP + COA + FOR + FUM + 3 NADPH + 2 NH4 + OAA + PYR + R5P ->
ACCOA + 8 ADP + CO2 + DTTP + H + H2O + 3 NADP + 6 PI + SUCC
0.52

The lumped reactions are sorted based on their carbon mole dTTP synthesis / carbon-mole glucose uptake yield.