Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 2;49(6):e342. doi: 10.1038/emm.2017.94

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Comparison of nucleocytoplasmic trafficking between young and old cells. (a) Young cell. Sp1 can activate the transcription of NCT genes, and the nuclear pores are functioning well for both mitogenic and apoptotic signals. (b) Old cell. Sp1 is vulnerable to degradation, resulting in defective functioning of nuclear pores, which restricts signal trafficking. GF, growth factor; AF, apoptosis-inducing factor; TF, transcription factor; NCT, nucleocytoplasmic trafficking genes; O-GlcNAc, O-linked N-acetyl glucosamine; ub, ubiquitination; thick arrow, high activity; thin arrow, low activity; dotted line, restricted activity.