Table 2. Echocardiographic measurement of inotropic and lusitropic response to the β-adrenoceptor stimulation in healthy and diabetic rats pretreated or not with atorvastatin.
| Percentage of baseline value | Healthy untreated (n = 10) | Healthy statin (n = 10) | Diabetic untreated (n = 9) | Diabetic statin (n = 8) |
|---|---|---|---|---|
| Heart rate | 118 ± 17▪ | 110 ± 40▪ | 130 ± 17▪ | 114 ± 18▪ |
| LVEF | 123 ± 13▪ | 120 ± 9▪ | 108 ± 6▪ | 128 ± 11▪*† |
| LVSF | 160 ± 19▪ | 157 ± 25▪ | 125 ± 16▪ | 167 ± 30▪*† |
| IVRT | 94 ± 21 | 61 ± 14 ▪† | 71 ± 34 | 82 ± 25 |
| DT | 99 ± 24 | 102 ± 35 | 100 ± 28 | 91 ± 40 |
| E/Ea | 102 ± 28 | 121 ± 47 | 84 ± 38 | 99 ± 21 |
Data are mean percentages of baseline values ± SD.
▪ p < 0.05 vs. baseline value
*: p<0.05 versus untreated healthy group
†: p<0.05 between statin and untreated rats in each group healthy or diabetic rats
‡: p<0.05 between healthy statin rats and diabetic statin rats. LVEF = left ventricular ejection fraction; LVSF = left ventricular shortening fraction; IVRT = isovolumic relaxation time; E = peak velocity of early mitral flow; DT = deceleration time of E wave, E/Ea = E peak velocity of early mitral flow/Ea early diastolic velocity of lateral mitral annulus ratio.