Table 4. Expression analysis of genes significantly modified by atorvastatin in diabetic left ventricle and involved in β-adrenergic signaling.

Function	Gene	Gene expression fold change
		Diabetic treated/diabetic control	Diabetic/healthy
cAMP production	Adenylate Cyclase 4 (ADCY4)	+ 1.9	+ 1.6*
cAMP degradation	Phosphodiesterase 2A (PDE2A)	+ 1.6	+ 1.0
Contraction effectors	Troponin C type 1 (TNNC1)	- 2.0	- 2.0 *
	Myosin binding protein H-like (MYBPHL)	+ 2.8	- 2.5
	Myosin, heavy polypeptide 7Bβ (MYH7B) (predicted)	+ 2.6	+ 1.3*
Regulation pathways	Nitric Oxide synthase 3 (NOS3) (endothelial)	+ 3.5	- 2.0*
	Arrestin domain containing 1 (ARRDC1) (predicted)	+ 1.6	+ 1.4*
	Ras-related associated with diabetes (RRAD)	- 2.0	+ 1.0
	Rho-associated kinase 2 (ROCK2)	+1.9	+1.7*
	Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)	+ 1.7	+ 1.6*
	Phospholipase A2G4B (PLA2G4B) (predicted)	+ 1.7	+ 1.5*
	Phospholipase A2G5 (PLA2G5)	- 2.1	- 1.9 *

Data are mean. A gene expression fold change over ±1.5 was considered as significant.

*: p<0.05 between Diabetic Untreated versus Healthy Untreated rats left ventricles.